1379532-99-6Relevant articles and documents
A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity
Xia, Yi,Wang, Menghua,Demaria, Olivier,Tang, Jingjie,Rocchi, Palma,Qu, Fanqi,Iovanna, Juan L.,Alexopoulou, Lena,Peng, Ling
, p. 5642 - 5646 (2012)
A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.