1379595-60-4Relevant academic research and scientific papers
Solid-phase synthesis of lysobactin (katanosin B): Insights into structure and function
Hall, Edward A.,Kuru, Erkin,Vannieuwenhze, Michael S.
, p. 2730 - 2733 (2012)
The solid phase synthesis of the cyclic depsipeptide antibiotic lysobactin is described. The natural product was synthesized via a linear approach using mostly an Fmoc-strategy solid phase peptide synthesis (SPPS) with a single purification. A lysobactin analog has also been synthesized displaying nanomolar membrane disruption activity not seen with the natural product.
