1379654-70-2

Upstream product

• 138487-22-6 5-(4-chlorophenyl)-4-pentyn-1-ol 
• 1190875-78-5 (Z)-ethyl 5-(4-chlorophenyl)pent-2-en-4-ynoate 

Relevant academic research and scientific papers

Metal-catalyzed formation of 1,3-cyclohexadienes: A catalyst-dependent reaction

A metal-dependent and complementary catalytic method to synthesize the cyclohexadienes has been developed. When gold or indium salts were used as catalysts, 1,3-cyclohexadiene (1,3-CHD) could be obtained; when Cu(OTf)2 was used as the catalyst,

Total synthesis of polyene natural product dihydroxerulin by mild organocatalyzed dehydrogenation of alcohols

Polyene synthesis: An efficient approach to the total synthesis of polyene natural product dihydroxrulin (1) is described. A novel, mild, direct organocatalytic IBX-mediated dehydrogenation process of simple alcohols to enals has been developed, which serves as a key step in the synthesis (see scheme). Copyright

New synthetic approach for the construction of multisubstituted 2-acyl furans by the IBX-mediated cascade oxidation/cyclization of cis-2-En-4-yn-1-ols (IBX = 2-iodoxybenzoic acid)

A new approach for the construction of multisubstituted 2-acyl furans through cis-2-En-4-yn-1-ols (IBX=2-iodoxybenzoic acid)-mediated oxidation/cyclization in dimethyl sulfoxidse (DMSO) was developed. The results show that the introduction of an alkyl group at Cl provided a satisfactory yield of furan of 60% at 90°C. It is seen that IBX act as an electrophile to promote the cycloaddition of carbonyl group to the alkyne moiety. The furan derivatives are found to be useful synthetic intermediates for access to the compounds bearing biological activity. The studies also elucidate this reaction mechanism and extend the scope of synthetic utility of multisubstituted 2-acyl furans.