1379659-22-9Relevant academic research and scientific papers
Palladium-catalyzed desymmetrization of silacyclobutanes with alkynes: Enantioselective synthesis of silicon-stereogenic 1-sila-2-cyclohexenes and mechanistic considerations
Shintani, Ryo,Moriya, Kohei,Hayashi, Tamio
, p. 2902 - 2905 (2012/07/17)
A palladium-catalyzed enantioselective desymmetrization of silacyclobutanes with alkynes has been developed to give silicon-stereogenic 1-sila-2-cyclohexenes with high enantioselectivity. The products thus obtained undergo further derivatizations with complete stereoselectivity, and a new catalytic cycle involving alkyne coordination (oxidative cyclization)- transmetalation (σ-bond metathesis)-reductive elimination has also been proposed.
