1379677-58-3

Basic information

• Product Name: methyl (2E,5S,6R)-6-(benzyloxy)-5-hydroxy-7-methyloct-2-enoate
• Synonyms: methyl (2E,5S,6R)-6-(benzyloxy)-5-hydroxy-7-methyloct-2-enoate
• CAS NO: 1379677-58-3
• Molecular Weight: 292.375
• Mol File: 1379677-58-3.mol

Chemical Properties

• CAS DataBase Reference: methyl (2E,5S,6R)-6-(benzyloxy)-5-hydroxy-7-methyloct-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2E,5S,6R)-6-(benzyloxy)-5-hydroxy-7-methyloct-2-enoate(1379677-58-3)
• EPA Substance Registry System: methyl (2E,5S,6R)-6-(benzyloxy)-5-hydroxy-7-methyloct-2-enoate(1379677-58-3)

Safety Data

• Hazardous Substances Data: 1379677-58-3(Hazardous Substances Data)

Upstream product

• 623-43-8 crotonic acid methyl ester 
• 96925-01-8 (R)-2-(benzyloxy)-3-methylbutanal 

Downstream Products

• 1379677-69-6 C₂₀H₃₆O₃Si 
• 1379677-68-5 methyl (2E,5S,6R)-6-(benzyloxy)-5-[(tert-butyldimethylsilyl)oxy]-7-methyloct-2-enoate 

Relevant articles and documents

The vinylogous aldol reaction of unsaturated esters and enolizable aldehydes using the novel Lewis acid aluminum tris(2,6-di-2-naphthylphenoxide)

The synthesis of the novel Lewis acid, aluminum tris(2,6-di-2- naphthylphenoxide) (ATNP), and its use in the vinylogous aldol reaction between methyl crotonate and enolizable aldehydes are described. ATNP is related to Yamamoto's Lewis acid, aluminum tris(2,6-diphenylphenoxide) (ATPH), but the 2-naphthyl groups more effectively block the α-position of aldehydes, enabling the selective enolization of crotonate esters in the presence of enolizable aldehydes. Vinylogous aldol reactions then proceed smoothly and in high yields with a variety of substrates.