1379689-25-4Relevant academic research and scientific papers
Cooperative Lewis acid-onium salt catalysis as tool for the desymmetrization of meso-epoxides
Broghammer, Florian,Brodbeck, Daniel,Junge, Thorsten,Peters, René
supporting information, p. 1156 - 1159 (2017/01/25)
Epoxide desymmetrizations by bromide are very rare despite the large synthetic potential of chiral bromohydrins. Herein we present a new concept for epoxide desymmetrizations in which a bifunctional Lewis acid/ammonium salt catalyst allows for efficient enantio-selective epoxide ring openings by Br. With acetylbromide as a Br source bromohydrin esters are formed.
