1379785-63-3Relevant academic research and scientific papers
Highly enantioselective pictet-spengler reaction catalyzed by SPINOL-phosphoric acids
Huang, Dan,Xu, Fangxi,Lin, Xufeng,Wang, Yanguang
, p. 3148 - 3152 (2012/04/17)
Chiral SPINOL-phosphoric acids are highly enantioselective catalysts for the asymmetric Pictet-Spengler reaction of Nb-α-naphthylmethyl tryptamines with a series of aliphatic and aromatic aldehydes, affording optically active tetrahydro-β-carbolines in excellent yields and ee values. The current protocol has been applied in the asymmetric total synthesis of (-)-harmicine. Copyright
