1379822-11-3

Upstream product

• 1379822-10-2 ((4,6-difluoro-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) 
• 28342-75-8 1,5-dibromo-2,4-difluorobenzene 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1379822-15-7 4,6-difluoro-1,3-bis(1-mesityl-1H-1,2,3-triazol-4-yl)benzene 
• 1436919-15-1 1,5-diethynyl-2,4-bis(p-tolyloxy)benzene 

Relevant academic research and scientific papers

N,N-Dialkylhydrazones as Versatile Umpolung Reagents in Enantioselective Anion-Binding Catalysis

An enantioselective anion-binding organocatalytic approach with versatile N,N-dialkylhydrazones (DAHs) as polarity-reversed (umpolung) nucleophiles is presented. For the application of this concept, a highly ordered hydrogen-bond (HB) network between a carefully selected CF3-substituted triazole-based multidentate HB-donor catalyst, the ionic substrate and the hydrazone in a supramolecular chiral ion-pair complex was envisioned. The formation of such a network was further supported by both experimental and computational studies, which showed the crucial role of the anion as a template unit. The asymmetric Reissert-type reaction of quinolines as a model test reaction chemoselectively delivered highly enantiomerically enriched hydrazones (up 95:5 e.r.) that could be further derivatized to value-added compounds with up to three stereocenters.

POLYCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.

An alternative role for acetylenes: Activation of fluorobenzenes toward nucleophilic aromatic substitution

Acetylenes are increasingly versatile functional groups for a range of complexity-building organic transformations and for the construction of desirable molecular architectures. Herein we disclose a previously underappreciated aspect of arylacetylene reac

Ruthenium(II) photosensitizers of tridentate click-derived cyclometalating ligands: A joint experimental and computational study

A systematic series of heteroleptic bis(tridentate)ruthenium(II) complexes of click-derived 1,3-bis(1,2,3-triazol-4-yl)benzene N^C^N-coordinating ligands was synthesized, analyzed by single crystal X-ray diffraction, investigated photophysically and electrochemically, and studied by computational methods. The presented comprehensive characterization allows a more detailed understanding of the radiationless deactivation mechanisms. Furthermore, we provide a fully optimized synthesis and systematic variations towards redox-matched, broadly and intensely absorbing, cyclometalated ruthenium(II) complexes. Most of them show a weak room-temperature emission and a prolonged excited-state lifetime. They display a broad absorption up to 700 nm and high molar extinction coefficients up to 20 000 M-1 cm-1 of the metal-to-ligand charge transfer bands, resulting in a black color. Thus, the complexes reveal great potential for dye-sensitized solar-cell applications. Making sense of sensitization: A systematic series of heteroleptic bis(tridentate) ruthenium(II) complexes of 1,3-bis(1,2,3-triazol-4-yl)benzene N C N-coordinating ligands and 2,2′:6′,2′′-terpyridine was synthesized, analyzed by single-crystal X-ray diffraction, investigated photophysically and electrochemically, and studied by computational methods (see figure) revealing great potential for application in dye-sensitized solar cells. Copyright