137985-52-5Relevant academic research and scientific papers
METABOLIC FORMATION AND CHEMICAL SYNTHESIS OF 5,6-CYCLOPENTENO-4,11-DIHYDRO-3H-PYRIDOCARBAZOL-3-ONE, THE MAJOR INTESTINAL BACTERIAL METABOLITE OF THE PYROLYSIS MUTAGEN 5,6-CYCLOPENTENO-11H-PYRIDOCARBAZOLE (LYS-P-1)
Kingston, David G. I.,Shu, Yue-Zhong,Tassel, Roger L. Van,Wilkins, Tracy D.
, p. 1821 - 1830 (2007/10/02)
Anaerobic incubation of the lysine pyrolysis mutagen 5,6-cyclopenteno-11H-pyridocarbazole (Lys-P-1,3) with human intestinal bacterial mixtures yielded the major metabolite 5,6-cyclopenteno-4,11-dihydro-3H-pyridocarbazol-3-one (3-OH-Lys-P-1,4).The metabolite (4) has been synthesized from 4-aminoindane in six steps.NAD and NADP significantly enhanced the metabolism, suggesting that the transformation of 3 leading to 4 involves a hydration and subsequent dehydrogenation processes.
