1380077-07-5

Basic information

• Product Name: (R)-2-amino-4,5,6-triphenyl-4H-pyran-3-carbonitrile
• Synonyms: (R)-2-amino-4,5,6-triphenyl-4H-pyran-3-carbonitrile
• CAS NO: 1380077-07-5
• Molecular Weight: 350.42
• Mol File: 1380077-07-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-amino-4,5,6-triphenyl-4H-pyran-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-amino-4,5,6-triphenyl-4H-pyran-3-carbonitrile(1380077-07-5)
• EPA Substance Registry System: (R)-2-amino-4,5,6-triphenyl-4H-pyran-3-carbonitrile(1380077-07-5)

Safety Data

• Hazardous Substances Data: 1380077-07-5(Hazardous Substances Data)

Upstream product

• 7474-65-9 (E)-2-phenylchalcone 
• 109-77-3 malononitrile 

Relevant articles and documents

Enantioselective synthesis of 2-amino-4H-pyrans via the organocatalytic cascade reaction of malononitrile and α-substituted chalcones

An organocatalytic cascade reaction of malononitrile and α-substituted chalcones has been developed for the synthesis of chiral multisubstituted 2-amino-4H-pyran derivatives. A series of chiral primary/tertiary amines and cinchona alkaloids were examined as the catalysts. Quinine was found to be the most efficient catalyst in the absence of any additive. The α-substitutents of the chalcones had a siginificant effect on the yield and the enantioselectivity. A number of multisubstituted 2-amino-4H-pyrans were obtained in excellent yields and enantioselectivities.