1380092-85-2Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of 9-alkoxy-6,7-dihydro-2 H-benzo[c][1,2,4]triazolo[4,3-a]azepin-3[5 H[-ones
Piao, Feng-Yu,Wei, Cheng-Xi,Han, Rong-Bi,Zhang, Wen-Bin,Zhang, Wei,Jiang, Ri-Shan
experimental part, p. 2337 - 2345 (2012/08/27)
A series of novel 9-alkoxy-6,7-dihydro-2H-benzo[c][1,2,4]triazolo[4,3-a] azepin-3(5H)-one derivatives was designed and synthesized starting from 2,3,4,5-tetrahydro-7-hydroxy-1H-2-benzazepin-1-one. The structures of these compounds were confirmed by mass, 1H NMR infrared spectra, and elemental analysis. Their anticonvulsant activity was evaluated by maximal electroshock (MES) test, and their neurotoxic effects were determined by the rotarod neurotoxicity test. The results shown that 3k was the most active compound with median effective dose (ED50) of 27.3mg/kg, median toxicity dose (TD50) of 118.3mg/kg, and protective index (PI) of 4.3. Possible structure-activity relationship is discussed.
