1380169-52-7Relevant academic research and scientific papers
Rhenium-catalyzed regioselective synthesis of multisubstituted pyridines from β-enamino ketones and alkynes via C-C bond cleavage
Yamamoto, Shun-Ichi,Okamoto, Kana,Murakoso, Makiko,Kuninobu, Yoichiro,Takai, Kazuhiko
supporting information; experimental part, p. 3182 - 3185 (2012/07/28)
A new method is described for the regioselective synthesis of multisubstituted pyridine derivatives. Treatment of N-acetyl β-enamino ketones with alkynes in the presence of the rhenium catalyst, Re 2(CO)10, gives multisubstituted pyridines regioselectively. In this reaction, the N-acetyl moieties are important for the selective formation of the multisubstituted pyridines. This reaction proceeds via insertion of alkynes into a carbon-carbon single bond of β-enamino ketones, intramolecular nucleophilic cyclization, and elimination of acetic acid.
