1380182-34-2Relevant academic research and scientific papers
Merging domino and redox chemistry: Stereoselective access to di- and trisubstituted β,γ-unsaturated acids and esters
Tejedor, David,Mendez-Abt, Gabriela,Cotos, Leandro,Garcia-Tellado, Fernando
supporting information; experimental part, p. 3468 - 3472 (2012/04/23)
Merging is the game! The coupling of a domino reaction and an internal neutral redox reaction constitutes an excellent manifold for the stereoselective synthesis of di- and trisubstituted olefins featuring a malonate unit, an ester, or a free carboxylic acid as substituents at the allylic position (see scheme; MW=microwave). The reaction utilizes simple starting materials (propargyl vinyl ethers), methanol or water as solvents, and a very simple and bench-friendly protocol. Copyright
