1380208-74-1

Basic information

• Product Name: 1-(2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)butan-2-one
• Synonyms: 1-(2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)butan-2-one
• CAS NO: 1380208-74-1
• Molecular Weight: 297.372
• Mol File: 1380208-74-1.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)butan-2-one(1380208-74-1)
• EPA Substance Registry System: 1-(2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)butan-2-one(1380208-74-1)

Safety Data

• Hazardous Substances Data: 1380208-74-1(Hazardous Substances Data)

Upstream product

• 78317-79-0 2-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 78-93-3 butanone 

Relevant articles and documents

CDC reactions of N-aryl tetrahydroisoquinolines using catalytic amounts of DDQ: C-H activation under aerobic conditions

An oxidative cross-dehydrogenative coupling (CDC) reaction for the formation of C-C and C-P bonds is disclosed using a catalytic amount of DDQ (10 mol %) under aerobic conditions (see scheme). This unprecedented environmentally benign strategy of using AI

Visible light promoted photoredox C(sp3)-H bond functionalization of tetrahydroisoquinolines in flow

A merger of organocatalysis and visible light photoredox catalysis performed in flow allowed access to a wide range of functionalizedN-aryl-substituted tetrahydroisoquinolines (THIQs) in a formal C-H oxidation/Mannich reaction. Strecker type functionaliza

Dehydrogenative C(sp3)-H bond functionalization of tetrahydroisoquinolines mediated by organic oxidants under mild conditions

The organocatalyzed Mannich reaction of unsubstituted and N-aryl-substituted tetrahydroisoquinolines (THIQs) and the Strecker reaction of several N-aryl-substituted THIQs through dehydrogenative C(sp3)-H bond functionalization (cross-dehydrogenative coupling) promoted by organic single electron oxidants DDQ and IBX are presented. The C-H oxidation/Mannich reaction of less reactive N-aryl substituted pyrrolidines is achieved via metal catalyzed photoredox catalysis. Operationally simple procedures provide desired products in an effective and time preserving manner.