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CAS

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1380228-27-2

5-((2-iodophenylamino)(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1380228-27-2 Structure

  • Basic information

    1. Product Name: 5-((2-iodophenylamino)(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
    2. Synonyms: 5-((2-iodophenylamino)(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione
    3. CAS NO:1380228-27-2
    4. Molecular Formula:
    5. Molecular Weight: 419.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1380228-27-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-((2-iodophenylamino)(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-((2-iodophenylamino)(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione(1380228-27-2)
    11. EPA Substance Registry System: 5-((2-iodophenylamino)(methylthio)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione(1380228-27-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1380228-27-2(Hazardous Substances Data)

1380228-27-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1380228-27-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,0,2,2 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1380228-27:
(9*1)+(8*3)+(7*8)+(6*0)+(5*2)+(4*2)+(3*8)+(2*2)+(1*7)=142
142 % 10 = 2
So 1380228-27-2 is a valid CAS Registry Number.

1380228-27-2Relevant articles and documents

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

Pirali, Tracey,Ciraolo, Elisa,Aprile, Silvio,Massarotti, Alberto,Berndt, Alex,Griglio, Alessia,Serafini, Marta,Mercalli, Valentina,Landoni, Clarissa,Campa, Carlo Cosimo,Margaria, Jean Piero,Silva, Rangel L.,Grosa, Giorgio,Sorba, Giovanni,Williams, Roger,Hirsch, Emilio,Tron, Gian Cesare

, p. 1542 - 1554 (2017)

Activation of the phosphoinositide 3-kinase (PI3K) pathway is a key signaling event in cancer, inflammation, and other proliferative diseases. PI3K inhibitors are already approved for some specific clinical indications, but their systemic on-target toxicity limits their larger use. In particular, whereas toxicity is tolerable in acute treatment of life-threatening diseases, this is less acceptable in chronic conditions. In the past, the strategy to overcome this drawback was to block selected isoforms mainly expressed in leukocytes, but redundancy within the PI3K family members challenges the effectiveness of this approach. On the other hand, decreasing exposure to selected target cells represents a so-far unexplored alternative to circumvent systemic toxicity. In this manuscript, we describe the generation of a library of triazolylquinolones and the development of the first prodrug pan-PI3K inhibitor.

QUINOLIN-4 (1H) -ONE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASES

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Paragraph 0081; 0082, (2013/09/26)

Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phos

QUINOLIN-4 (1H) -ONE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASES

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Page/Page column 44-45, (2012/06/16)

Compounds of Formula (I): able to inhibit kinase activity, in particular Phosphatidylinositol 3-Kinases activity. The disclosure also relates to the use of compounds of Formula (I) for treatment of pathological conditions associated to alterations in Phos

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