1380228-68-1

Basic information

• Product Name: benzyl tert-butyl (2,4-difluoro-1,3-phenylene)dicarbamate
• Synonyms: benzyl tert-butyl (2,4-difluoro-1,3-phenylene)dicarbamate
• CAS NO: 1380228-68-1
• Molecular Weight: 378.376
• Mol File: 1380228-68-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl tert-butyl (2,4-difluoro-1,3-phenylene)dicarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl tert-butyl (2,4-difluoro-1,3-phenylene)dicarbamate(1380228-68-1)
• EPA Substance Registry System: benzyl tert-butyl (2,4-difluoro-1,3-phenylene)dicarbamate(1380228-68-1)

Safety Data

• Hazardous Substances Data: 1380228-68-1(Hazardous Substances Data)

Upstream product

• 535170-17-3 tert-butyl (2,6-difluoro-3-nitrophenyl)carbamate 
• 83141-10-0 2,6-difluoro-3-nitrobenzoic acid 
• 501-53-1 benzyl chloroformate 
• 535170-20-8 tert-butyl (3-amino-2,6-difluorophenyl)carbamate 
• 260552-98-5 2,6-difluoro-3-nitrobenzoic acid chloride 
• 385-00-2 2,6-difluorobenzoic acid 

Downstream Products

• 1380229-22-0 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-1-methyl-1H-pyrazole-4-sulfonamide 
• 1380228-63-6 N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-pyrazole-4-sulfonamide 
• 1380229-23-1 5-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide 
• 1380228-64-7 N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-5-chlorothiophene-2-sulfonamide 
• 1380228-71-6 benzyl 2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl carbamate 
• 1380228-73-8 2,6-difluoro-N₁-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)benzene-1,3-diamine 
• 1380228-74-9 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-3-(trifluoromethyl)benzenesulfonamide 
• 1380227-98-4 N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-3-(trifluoromethyl)benzenesulfonamide 
• 1380228-76-1 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-4-(trifluoromethyl)benzenesulfonamide 
• 1380228-00-1 N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-4-(trifluoromethyl)benzenesulfonamide 
• 1380228-78-3 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)thiophene-2-sulfonamide 
• 1380228-02-3 N-(3-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2,4-difluorophenyl)thiophene-2-sulfonamide 
• 1380228-80-7 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)propane-1-sulfonamide 
• 1380228-04-5 N-(3-(3-(9H-purine-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl) propane-1-sulfonamide 

Relevant articles and documents

PYRIDINE DERIVATIVE INHIBITING RAF KINASE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF

The present invention provides a novel pyridine derivative, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient. The pyridine derivative according to the present invention inhibits Raf kinase (B-Raf, Raf-1, or B-RafV600E) and a vascular endothelial growth factor receptor (VEGFR2) involved in angiogenesis, and thus, can be favorably used for the prevention or treatment of melanoma, colorectal cancer, prostate cancer, thyroid cancer, lung cancer, pancreatic cancer, ovarian cancer, or the like, which is induced by RAS mutation.