1380239-83-7Relevant academic research and scientific papers
Enantioselective α-vinylation of aldehydes via the synergistic combination of copper and amine catalysis
Skucas, Eduardas,MacMillan, David W. C.
, p. 9090 - 9093 (2012/07/14)
The enantioselective α-vinylation of aldehydes using vinyl iodonium triflate salts has been accomplished via the synergistic combination of copper and chiral amine catalysis. These mild catalytic conditions provide a direct route for the enantioselective construction of enolizable α-formyl vinylic stereocenters without racemization or olefin transposition. These high-value coupling adducts are readily converted into a variety of useful olefin synthons.
