1380299-63-7Relevant academic research and scientific papers
Methods for preparation of apremilast
-
Page/Page column 6-7, (2021/05/19)
The present invention discloses a method for preparation of Apremilast. β-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.
CHIRAL DIENE LIGANDS, A FABRICATION METHOD THEREOF AND APPLICATIONS THEREOF
-
Paragraph 0022; 0023, (2013/04/24)
The present invention proposes a chiral diene ligand, a fabrication method thereof and applications thereof. The chiral diene ligand is a bicyclo[2.2.1] diene ligand having structural specificity and high stability, which favors the bicyclo[2.2.1] diene l
Expanding the C1-symmetric bicyclo[2.2.1]heptadiene ligand family: Highly enantioselective synthesis of cyclic β-aryl-substituted carbonyl compounds
Liu, Chia-Chen,Janmanchi, Damodar,Chen, Chun-Chih,Wu, Hsyueh-Liang
supporting information; experimental part, p. 2503 - 2507 (2012/06/04)
The efficient preparation of highly enantioenriched cyclic β-aryl-substituted carbonyl compounds has been achieved through the Rh I-catalyzed asymmetric 1,4-addition of an array of arylboronic acids to cyclic α,β-unsaturated carbonyl compounds. In the presence of 0.1 or 0.5 mol-% of the RhI/1g complex, the products of conjugate addition were isolated in 89 to 98%ee and in good to excellent yield.
