1380334-27-9Relevant academic research and scientific papers
Base-catalyzed direct aldolization of α-alkyl-α-hydroxy trialkyl phosphonoacetates
Corbett, Michael T.,Uraguchi, Daisuke,Ooi, Takashi,Johnson, Jeffrey S.
, p. 4685 - 4689 (2012)
Pass the P: Catalytic direct aldol addition of α-hydroxy trialkyl phosphonacetates to aldehydes affords α-hydroxy-β-phosphonyloxy ester products (see scheme). The fully substituted glycolate enolate intermediate is generated in situ under mild conditions by a [1,2] phosphonate-phosphate rearrangement. High enantioselectivity and dramatic enhancement of reaction diastereocontrol is realized by the application of chiral iminophosphorane catalysts. Copyright
