1380394-75-1Relevant academic research and scientific papers
Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives
Zhang, Jian,Mu, Keman,Yang, Peng,Feng, Xinqian,Zhang, Di,Fan, Xiangyu,Wang, Qiantao,Mao, Shengjun
, (2021/08/03)
In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on phenyl ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.
Electrochemical Synthesis Strategy for Cvinyl-CF3 Compounds through Decarboxylative Trifluoromethylation
Hong, Huanliang,Li, Yibiao,Chen, Lu,Li, Bin,Zhu, Zhongzhi,Chen, Xiuwen,Chen, Ling,Huang, Yubing
, p. 5980 - 5986 (2019/05/10)
An efficient decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids using the Langlois reagent as a trifluoromethyl precursor has been achieved by an electro-oxidative strategy. Under catalyst-free and external oxidant-free electrolysis
Copper/silver-mediated decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids with CF3SO2Na
Yin, Jun,Li, Yaming,Zhang, Rong,Jin, Kun,Duan, Chunying
supporting information, p. 607 - 612 (2014/03/21)
A copper/silver-catalyzed decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids with CF3SO2Na was performed under relatively mild conditions. The reaction shows high E/Z selectivity and wide substrate tolerance. Ag2CO3 plays an important role in promoting the decarboxylation process. Georg Thieme Verlag Stuttgart New York.
Iron-mediated decarboxylative trifluoromethylation of α,β- unsaturated carboxylic acids with trifluoromethanesulfinate
Patra, Tuhin,Deb, Arghya,Manna, Srimanta,Sharma, Upendra,Maiti, Debabrata
supporting information, p. 5247 - 5250 (2013/09/02)
A sustainable FeCl3-mediated method has been developed for the decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids by using NaSO2CF3 as an economic and stable CF 3 source. The reaction proceeds under mild condition and tolerates various functional groups. Advantageously, this method does not require an inert atmosphere and proceeds well in air at ambient temperature. A sustainable FeCl3-mediated method has been developed for the decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids by using NaSO2CF3 as an economic and stable CF3 source. This method does not require an inert atmosphere and proceeds well in air at ambient temperature. Copyright
Copper-catalyzed Di- and trifluoromethylation of α,β-unsaturated carboxylic acids: A protocol for vinylic fluoroalkylations
He, Zhengbiao,Luo, Tao,Hu, Mingyou,Cao, Yanjing,Hu, Jinbo
supporting information; experimental part, p. 3944 - 3947 (2012/05/20)
Dual action: The Lewis acid CuF2·2 H2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity. Copyright
