1380397-32-9Relevant articles and documents
Absolute asymmetric synthesis of tertiary α-amino acids
Mai, Thi Thoa,Branca, Mathieu,Gori, Didier,Guillot, Régis,Kouklovsky, Cyrille,Alezra, Valérie
, p. 4981 - 4984 (2012)
Frozen: The spontaneous crystallization of an achiral compound in a chiral conformation is used as the unique source of chirality in an absolute asymmetric synthesis of tertiary amino acids. The dynamic axial chirality of tertiary aromatic amides is frozen in a crystal (see picture) and is responsible for the stereoselectivity of the deprotonation/alkylation (see scheme). α-Amino acid derivatives are synthesized in up to 96% ee. Copyright