1380402-08-3Relevant academic research and scientific papers
Enantioselective synthesis of imidazolines with quaternary stereocenters by organocatalytic reaction of N-(heteroarenesulfonyl)imines with isocyanoacetates
Nakamura, Shuichi,Maeno, Yuri,Ohara, Mutsuyo,Yamamura, Akiko,Funahashi, Yasuhiro,Shibata, Norio
supporting information; experimental part, p. 2960 - 2963 (2012/08/07)
An organocatalytic enantioselective Mannich-type reaction of isocyanoacetate with N-sulfonylimines catalyzed by chiral thioureas derived from quinine yielded 2-imidazolines with high diastereo- and enantioselectivities (up to >99:1 dr. and 96% ee). This reaction provided a convenient route to access various imidazolines and related α,β-diamino acids having a quaternary carbon center in high enantiomeric purities.
