1380411-53-9Relevant academic research and scientific papers
Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts
Gieling, Roben G.,Babur, Muhammad,Mamnani, Lupti,Burrows, Natalie,Telfer, Brian A.,Carta, Fabrizio,Winum, Jean-Yves,Scozzafava, Andrea,Supuran, Claudiu T.,Williams, Kaye J.
, p. 5591 - 5600 (2012)
A panel of compounds belonging to the underexposed sulfamate class of carbonic anhydrase (CA, EC 4.2.1.1) inhibitors was generated that displayed high specificity at nanomolar levels for the tumor-associated CA IX/XII isoforms. Three of the specific CA IX
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
Winum, Jean-Yves,Carta, Fabrizio,Ward, Carol,Mullen, Peter,Harrison, David,Langdon, Simon P.,Cecchi, Alessandro,Scozzafava, Andrea,Kunkler, Ian,Supuran, Claudiu T.
supporting information; experimental part, p. 4681 - 4685 (2012/07/31)
A series of 50 sulfamates were obtained by reacting 4-aminophenol with isocyanates followed by sulfamoylation. Most of the new compounds were nanomolar inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII, whereas the
