1380489-87-1

Upstream product

• 1380489-86-0 2-azidoethyl 3-O-benzyl-4,6-O-benzylidene-2-O-(p-methoxybenzyl)-β-D-mannopyranoside 
• 159353-70-5 phenyl 2-O-p-methoxybenzyl-3-O-benzyl-4,6-O-benzylidene-1-deoxy-1-thio-α-D-mannopyranoside 

Downstream Products

• 1380490-00-5 1-(2-(3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyloxy)ethyl)-4-(3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyloxymethyl)-1,2,3-triazole 
• 1380489-92-8 1-[2-((2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-(1->2)-(3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyloxy))ethyl]-4-hydroxymethyl-1,2,3-triazole 
• 1380489-91-7 1-(2-(3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyloxy)ethyl)-4-hydroxymethyl-1,2,3-triazole 
• 1380489-88-2 2-azidoethyl (2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-(1->2)-3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranoside 
• 1583320-63-1 2-azidoethyl 3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl-(1→2)-3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranoside 
• 1583320-62-0 2-azidoethyl 3-O-benzyl-4,6-O-benzylidene-2-O-p-methoxybenzyl-β-D-mannopyranosyl-(1→2)-3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranoside 
• 1421193-26-1 C₂₉H₃₁N₃O₆ 
• 1421193-23-8 2-azidoethyl 2,3,6-tri-O-benzyl-β-D-mannopyranoside 
• 1421193-33-0 2-azidoethyl O-(6-O-benzyl-3,4-O-isopropylidene-β-D-galactopyranosyl)-(1→4)-2,3,6-tri-O-benzyl-β-D-mannopyranoside 

Relevant academic research and scientific papers

Oligosaccharides and peptide displayed on an amphiphilic polymer enable solid phase assay of hapten specific antibodies

Copovidone, a copolymer of vinyl acetate and N-vinyl-2-pyrrolidone, was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and after deacetylation the polymer was functionalized by introduction of amino, azide, and alkyne pendant groups to allow attachment of glycans and peptide. Candida albicans β-mannan trisaccharides 1 and 2 and M. tuberculosis arabinan hexasaccharide 3 with appropriate tethers were conjugated to the polymers by squarate or click chemistry. C. albicans T-cell peptide 4 bearing a C-terminal I?μ -azidolysine was also conjugated to copovidone by click chemistry. The resulting conjugates provide convenient non-protein-based antigens that are readily adsorbed on ELISA plates, and display excellent characteristics for assay of antibody binding to the haptenic group of interest. Copovidone and BSA glycoconjugates exhibited similar adsorption characteristics when used to coat ELISA plates, and both conjugates were optimal when used as coating solutions at low nanogram/mL concentrations. Provided that the copovidone conjugated glycan is stable to acid, assay plates can be easily processed for reuse at least three times without detectable variation or degradation in ELISA readout.

Synthesis and immunological screening of β-linked mono- and divalent mannosides

Three different β-linked divalent mannosides, along with their corresponding monovalent counterparts, have been designed and chemically synthesized by coupling the corresponding propargyl (propargyl alcohol in the case of the monovalent compounds) and 2-azidoethyl glycosides by using an efficient click chemistry protocol. Crich's β-mannosylation methodology was applied to the construction of the β-mannosidic linkages. All the glycosylation reactions gave moderate-to-good yields with high selectivities. A competitive inhibition enzyme-linked immunosorbent assay (ELISA) was performed to determine the inhibition, by the synthesized mannosides, of specific human IgG binding to low-molecular-weight Candida albicans mannan; moderate inhibition capacity was observed for some of the compounds. Copyright