1380489-96-2

Upstream product

• 159353-70-5 phenyl 2-O-p-methoxybenzyl-3-O-benzyl-4,6-O-benzylidene-1-deoxy-1-thio-α-D-mannopyranoside 
• 1380489-95-1 propargyl 3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranoside 
• 159407-17-7 phenyl 2,3-di-O-benzyl-4,6-O-benzylidene-1-thio-α-D-mannopyranoside 
• 1380489-94-0 propargyl 3-O-benzyl-4,6-O-benzylidene-2-O-(p-methoxybenzyl)-β-D-mannopyranoside 

Downstream Products

• 1380490-01-6 1-[2-((2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-(1->2)-(3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyloxy))ethyl]-4-[(2,3-di-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyl)-(1->2)-(3-O-benzyl-4,6-O-benzylidene-β-D-mannopyranosyloxymethyl)]-1,2,3-triazole 

Relevant academic research and scientific papers

Synthesis and immunological screening of β-linked mono- and divalent mannosides

Three different β-linked divalent mannosides, along with their corresponding monovalent counterparts, have been designed and chemically synthesized by coupling the corresponding propargyl (propargyl alcohol in the case of the monovalent compounds) and 2-azidoethyl glycosides by using an efficient click chemistry protocol. Crich's β-mannosylation methodology was applied to the construction of the β-mannosidic linkages. All the glycosylation reactions gave moderate-to-good yields with high selectivities. A competitive inhibition enzyme-linked immunosorbent assay (ELISA) was performed to determine the inhibition, by the synthesized mannosides, of specific human IgG binding to low-molecular-weight Candida albicans mannan; moderate inhibition capacity was observed for some of the compounds. Copyright