1380538-79-3Relevant academic research and scientific papers
Organocatalytic Stereoselective Iodoamination of Alkenes
Mizar, Pushpak,Burrelli, Alessandra,Günther, Erika,S?ftje, Martin,Farooq, Umar,Wirth, Thomas
, p. 13113 - 13116 (2014)
A new chiral thiohydantoin catalyst is used for the stereoselective iodoamination of alkenes. N-iodosuccinimide as the source of the electrophilic iodine is activated by catalytic amounts of different additives which also influence the regioselectivity of some cyclizations.
Catalytic enantioselective alkene aminohalogenation/cyclization involving atom transfer
Bovino, Michael T.,Chemler, Sherry R.
, p. 3923 - 3927 (2012/05/20)
Problem solved: The title reaction was used for the synthesis of chiral 2-bromo, chloro, and iodomethyl indolines and 2-iodomethyl pyrrolidines (see scheme). Stereocenter formation is believed to occur by enantioselective cis aminocupration and C-X bond formation is believed to occur by atom transfer. The ultility of the products as versatile synthetic intermediates was demonstrated, as was a radical cascade cyclization sequence. Copyright
