1380545-65-2Relevant academic research and scientific papers
Synthesis and in vitro activity of novel 2-(benzylthio)-4-chloro-5-(1,3,4- oxadiazol-2-yl)benzenesulfonamide derivatives
Brozewicz, Kamil,Ssawinski, Jaroslaw
, p. 975 - 984 (2012/08/29)
Two series of novel 4-chloro-2-(benzylthio)-5-(1,3,4-oxadiazol-2-yl) benzenesulfonamides and their N-aroyl derivatives have been synthesized and evaluated for in vitro anticancer activity against the full NCI-60 cell line panel. Most of the compounds exhibited antiproliferative activity. Among them a compound bearing an N-(thien-2-ylcarbonyl) moiety showed broad-spectrum activity with 50% growth inhibition (GI50) values in the range of 2.02-7.82 μM over 50 cell lines. The Author(s) 2012.
