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1380547-17-0

N1,N4-bis(3-hydroxyphenyl)-3,6-dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1380547-17-0 Structure

  • Basic information

    1. Product Name: N1,N4-bis(3-hydroxyphenyl)-3,6-dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide
    2. Synonyms: N1,N4-bis(3-hydroxyphenyl)-3,6-dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide
    3. CAS NO:1380547-17-0
    4. Molecular Formula:
    5. Molecular Weight: 382.379
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1380547-17-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N1,N4-bis(3-hydroxyphenyl)-3,6-dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N1,N4-bis(3-hydroxyphenyl)-3,6-dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide(1380547-17-0)
    11. EPA Substance Registry System: N1,N4-bis(3-hydroxyphenyl)-3,6-dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide(1380547-17-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1380547-17-0(Hazardous Substances Data)

1380547-17-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1380547-17-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,0,5,4 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1380547-17:
(9*1)+(8*3)+(7*8)+(6*0)+(5*5)+(4*4)+(3*7)+(2*1)+(1*7)=160
160 % 10 = 0
So 1380547-17-0 is a valid CAS Registry Number.

1380547-17-0Downstream Products

1380547-17-0Relevant articles and documents

A compound meta-hydroxy phenyl tetrazine dimethyl amide and its preparation and use

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Paragraph 0024; 0025, (2016/11/28)

The invention discloses a new compound, N1,N4-di(3-hydroxyphenyl)-3,6-dimethyl-1,2,4,5-tetrazine-1,4-dicarbonamide shown in formula (I), and preparation and application thereof. The preparation of the compound comprises the steps of using 3,6-dimethyl-1,6-dihydro-1,2,4,5-tetrazine and bis(trichloromethyl) carbonate as raw materials to react with m-hydroxyaniline in an organic solvent in the presence of alkaline catalyst. The compound provided by the invention is applied for preparing medicines for treatment and prevention of human gastric cancer, ovarian cancer, liver cancer, breast cancer or lung cancer. According to the invention, the compound is rational in design, easy in operation, low in production cost and easy to obtain raw materials, and is suitable for industrialized application, and a new choice for screening anti-tumor medicines is provided.

Synthesis, Structure Analysis, and Antitumor Evaluation of 3,6-Dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide Derivatives

Rao, Guo-Wu,Guo, Yan-Mei,Hu, Wei-Xiao

experimental part, p. 973 - 976 (2012/08/08)

3,6-Dimethyl-1,2,4,5-tetrazine-1,4-dicarboxamide derivatives were synthesized, and their structures were confirmed by single-crystal X-ray diffraction. This reaction yields the 1,4-dicarboxamide derivatives rather than the 1,2-dicarboxamide derivatives. Their invitro antitumor activities were evaluated against SGC-7901, HO-8910, MCF-7, and A-549 cells. The results showed several compounds to be endowed with cytotoxicity in the low micromolar range. One compound (IC50=0.57μM) was further evaluated invivo against an A-549 xenograft in BALB/cA nude mice; it effected 76.4% inhibition of tumor weight through intraperitoneal (i.p.) administration of 40mgkg-1 body weight. Moreover, its acute toxicity was evaluated, and the i.p. LD50 value was 325mgkg-1 in mice.

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