1380547-35-2Relevant academic research and scientific papers
Catalytic asymmetric synthesis of functionalized α,α- disubstituted α-amino acid derivatives from racemic unprotected α-amino acids via in-situ generated azlactones
Weber, Manuel,Frey, Wolfgang,Peters, Rene
, p. 1443 - 1449 (2012/07/13)
Masked and activated highly enantioenriched α,α-disubstituted α-amino acids with an additional adjacent stereocenter were formed by a tandem reaction involving five steps using racemic unprotected amino acid substrates. Key step is the 1,4-addition of in-situ generated azlactones to a broad number of enones. The products of this step-economic route can, e.g., be useful for a divergent and rapid access to biologically interesting unnatural glutamic acid derivatives. Copyright
