1380585-87-4

Upstream product

• 615-36-1 2-bromoaniline 
• 115363-92-3 N-(2-bromophenyl)-4-hydroxybutanamide 
• 1380585-86-3 N-benzyl-N-(2-bromophenyl)-4-hydroxybutanamide 

Downstream Products

• 1380585-96-5 (S)-N-(2-((S)-1-benzyl-3-(2-methylallyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380585-97-6 (S)-N-(2-((S)-1-benzyl-3-(3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380585-98-7 (S)-N-(2-((S)-1-benzyl-3-((E)-4-(ter t-butyldimethylsilyloxy)-3-methylbut-2-enyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380585-99-8 ethyl 2-(((S)-1-benzyl-3-(2-((S)-N,2-dimethylpropan-2-ylsulfinamido)ethyl)-2-oxoindolin-3-yl)methyl)acrylate 
• 1380586-00-4 (S)-N-(2-((R)-1-benzyl-3-(2-bromoallyl)-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380586-04-8 (S)-N-(2-((S)-1-benzyl-2-oxo-3-(prop-2-ynyl)indolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380586-05-9 (S)-N-(2-((S)-1-benzyl-2-oxo-3-(pent-2-ynyl)indolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380586-11-7 N-(2-(1-benzyl-3-hydroxy-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380585-85-2 (S)-N-(2-((S)-3-allyl-1-benzyl-2-oxoindolin-3-yl)ethyl)-N,2-dimethylpropane-2-sulfinamide 
• 1380585-88-5 (S)-N-benzyl-N-(2-bromophenyl)-4-(1,1-dimethylethylsulfinamido)butanamide 
• 1380585-84-1 (S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide 
• 1380585-95-4 C₂₁H₂₅BrN₂O₂S 

Relevant academic research and scientific papers

Copper catalyzed sequential arylation-oxidative dimerization of o-haloanilides: synthesis of dimeric HPI alkaloids

In this communication, we report a copper catalyzed sequential arylation-oxidative dimerization reaction as the key step for the synthesis of hexahydropyrroloindole alkaloids (+)-chimonanthine, (+)-folicanthine and (-)-calycanthine.

Copper-catalyzed arylation of o-bromoanilides: Highly flexible synthesis of hexahydropyrroloindole alkaloids

In the presence of catalytic amount of copper iodide, a remote amide-assisted intramolecular arylation followed by alkylation leads to a general and flexible synthetic method toward the synthesis of medicinally interesting hexahydropyrroloindole alkaloids.