1380592-77-7Relevant academic research and scientific papers
Highly efficient four-component synthesis of 2-amino-3-cyanopyridines using doped nano-sized copper(I) oxide (Cu2O) on melamine-formaldehyde resin
Behrouz, Somayeh
, p. 540 - 544 (2016)
A convenient and facile four-component synthesis is described of 2-amino-3-cyanopyridine derivatives from readily available starting materials catalysed by doped nano-sized Cu2O on melamine-formaldehyde resin (nano-Cu2O-MFR). In this method, treatment of different aldehydes, ketones, malononitrile, and ammonium acetate in refluxing H2O/EtOH (1:1) in the presence of doped nano-Cu2O-MFR as a highly efficient heterogeneous catalyst affords the corresponding 2-amino-3-cyanopyridines in good to excellent yields. The nano-Cu2O-MFR is a cheap and stable nano-catalyst that could be easily recovered and reused for many consecutive reaction runs without considerable decrease in its activity.
Ultrasound-promoted an efficient method for one-pot synthesis of 2-amino-4,6-diphenylnicotinonitriles in water: A rapid procedure without catalyst
Safari, Javad,Banitaba, Sayed Hossein,Khalili, Shiva Dehghan
experimental part, p. 1061 - 1069 (2012/07/03)
A green and convenient approach to the synthesis of 2-amino-4,6- diphenylnicotinonitriles via four-component reaction of malononitrile, aromatic aldehydes, acetophenone derivatives and ammonium acetate in water under ultrasound irradiation is described. The combinatorial synthesis was achieved for this methodology with applying ultrasound irradiation while making use of water as green solvent. In comparison to conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst are prominent features of this sonocatalyzed procedure.
