1380592-79-9Relevant academic research and scientific papers
Aqueous media preparation of 2-amino-4,6-diphenylnicotinonitriles using cellulose sulfuric acid as an efficient catalyst
Mansoor, Syed Sheik,Aswin, Krishnamoorthy,Logaiya, Kuppan,Sudhan, Prasanna Nithiya,Malik, Saleem
, p. 871 - 885 (2014)
A convenient approach to the synthesis of 2-amino-4,6- diphenylnicotinonitriles via four-component reaction of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate is described. The reactions were done in water as solvent using cellulose sulfuric acid as catalyst. This simple protocol offer advantages such as shorter reaction times, simple work-up procedure, excellent yields and catalyst recovery.
Synthesis of a novel acidic ionic liquid catalyst and its application for preparation of pyridines via a cooperative vinylogous anomeric-based oxidation
Rahmati, Mohammad,Habibi, Davood
, p. 1643 - 1661 (2021/01/20)
Abstract: In the current study, a novel acidic ionic liquid catalyst based on 8-hydroxyquinoline, namely 8,8′,8″-([1,3,5-triazine-2,4,6-triyl]tris[oxy])tris(1-sulfoquinolin-1-ium)chloride (TTS), was designed and synthesized. The structure of the prepared acidic ionic liquid (AIL) was fully investigated by using Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, thermogravimetric analysis/differential thermal analysis (TGA/DTA), 1HNMR, 13CNMR and mass spectroscopy. Then, the catalytic performance of described AIL was successfully inspected toward the four-component synthesis of pyridine derivatives via a cooperative vinylogous anomeric-based oxidation. Graphic abstract: Novel AIL (TTS) showed a very high efficiency in the synthesis of pyridines. [Figure not available: see fulltext.].
Design, synthesis, and evaluation of cyanopyridines as anti-colorectal cancer agents via inhibiting STAT3 pathway
Xu, Lingyuan,Shi, Lingxi,Qiu, Sensen,Chen, Siyu,Lin, Mengsha,Xiang, Youqun,Zhao, Chengguang,Zhu, Jiandong,Shen, Liqun,Zuo, Zhigui
, p. 3369 - 3381 (2019/10/21)
Background: Colorectal cancer is one of the common malignant tumors. Cyanopyridine and aminocyanopyridine having a carbon-nitrogen bond have been shown to have significant anticancer effects. STAT3 is a promising therapeutic target in multiple cancers. Ho
3-cyano-2-aminopyridine derivative and preparation method and application thereof
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Paragraph 0036; 0038; 0039; 0040; 0041, (2019/01/08)
The invention discloses a 3-cyano-2-aminopyridine derivative and a preparation method and an application thereof. The pyridine derivative is as shown in any one of 1) to 5): 1) a name is 2-amino-4-(4-bromophenyl)-6-(4-hydroxyphenyl)cyanopyridine; 2) 2-ami
Ultrasound-promoted an efficient method for one-pot synthesis of 2-amino-4,6-diphenylnicotinonitriles in water: A rapid procedure without catalyst
Safari, Javad,Banitaba, Sayed Hossein,Khalili, Shiva Dehghan
experimental part, p. 1061 - 1069 (2012/07/03)
A green and convenient approach to the synthesis of 2-amino-4,6- diphenylnicotinonitriles via four-component reaction of malononitrile, aromatic aldehydes, acetophenone derivatives and ammonium acetate in water under ultrasound irradiation is described. The combinatorial synthesis was achieved for this methodology with applying ultrasound irradiation while making use of water as green solvent. In comparison to conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst are prominent features of this sonocatalyzed procedure.
