1380650-74-7Relevant academic research and scientific papers
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 1
Delouvrie, Benedicte,Al-Kadhimi, Katherine,Arnould, Jean-Claude,Barry, Simon T.,Cross, Darren A.E.,Didelot, Myriam,Gavine, Paul R.,Germain, Herve,Harris, Craig S.,Hughes, Adina M.,Jude, David A.,Kendrew, Jane,Lambert-Van Der Brempt, Christine,Lohmann, Jean-Jacques,Menard, Morgan,Mortlock, Andrew A.,Pass, Martin,Rooney, Claire,Vautier, Michel,Vincent, Jennifer L.,Warin, Nicolas
, p. 4111 - 4116 (2012)
Potent antagonists of the integrin α5β1, which are RGD mimetics built from tyrosine are described. This letter describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the basic group and the
