1380681-59-3

Upstream product

• 913828-41-8 4-bromo-2-tert-butyldimethylsilyloxymethylfuran 
• 1380681-47-9 4-benzoyloxymethyl-2-tert-butyldimethylsiloxymethylfuran 
• 913828-42-9 5-({[t-butyl(dimethyl)silyl]oxy}methyl)-3-furaldehyde 
• 1380681-54-8 (1R,2S,3R,4S,5S)-5-benzoyloxymethyl-1-hydroxymethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid dibenzyl ester 
• 59413-71-7 (4-bromofuran-2-yl)methanol 
• 21921-76-6 4-bromo-2-furancarbaldehyde 

Relevant academic research and scientific papers

Synthesis of optically pure norcantharidin analogue NCA-01, a highly selective protein phosphatase 2B inhibitor, and its derivatives

An efficient synthetic route to optically pure norcantharidin analogue NCA-01, a highly selective inhibitor of protein phosphatase 2B (PP2B; calcineurin), has been developed. The absolute stereochemistry of the enantiomers was determined by X-ray crystallographic analysis. Optically pure NCA derivatives that had various substituents at the C1 position were synthesized in a similar manner. The PP2B-inhibitory activities of NCA-01 and its derivatives were independent of the enantiomeric form. NCA-01 dimethyl ester potently inhibited IL-2 production in Jurkat cells.