1380695-75-9

Upstream product

• 16382-18-6 5,6-dimethoxy-1H-indole-2-carboxylic acid ethyl ester 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 191341-02-3 ethyl 3-bromo-5,6-dimethoxy-1H-indole-2-carboxylate 
• 67492-50-6 (3,5-dichlorophenyl)boronic acid 

Downstream Products

• 1380695-48-6 3-(3,5-dichlorophenyl)-5,6-dihydroxy-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and agonistic activity at the GPR35 of 5,6-dihydroxyindole-2- carboxylic acid analogues

5,6-Dihydroxyindole-2-carboxylic acid (DHICA), an intermediate of melanin synthesis and an eumelanin building block, was recently discovered to be a GPR35 agonist with moderate potency. Here, we report the synthesis and pharmacological characterization of a series of DHICA analogues against GPR35 using both label-free dynamic mass redistribution and Tango β-arrestin translocation assays. This led to identification of novel GPR35 agonists with improved potency and/or having biased agonism.