13807-15-3Relevant articles and documents
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases
Schonbrunn, Ernst,Betzi, Stephane,Alam, Riazul,Martin, Mathew P.,Becker, Andreas,Han, Huijong,Francis, Rawle,Chakrasali, Ramappa,Jakkaraj, Sudhakar,Kazi, Aslamuzzaman,Sebti, Said M.,Cubitt, Christopher L.,Gebhard, Anthony W.,Hazlehurst, Lori A.,Tash, Joseph S.,Georg, Gunda I.
, p. 3768 - 3782 (2013/06/27)
Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC50 = 0.0009-0.0015 μM) from a