1380809-72-2

Upstream product

• 1380809-71-1 ethyl 5-amino-4-cyano-3-methylselenophene-2-carboxylate 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 1482541-19-4 4-cyano-5-ethoxymethyleneimino-3-methylselenophene-2-carboxylic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1380808-93-4 {4-[(3-chloro-4-fluorophenyl)amino]-5-methylselenopheno[2,3-d]pyrimidin-'6-yl}-N-(2-hydroxyethyl)carboxamide 
• 1380808-79-6 4-(3-chloro-4-fluorophenylamino)-5-methylselenopheno[2,3-d]pyrimidine-6-carboxylic acid 
• 1380809-32-4 sodium 4-[(3-chloro-4-fluorophenyl)amino]-5-methylselenopheno[2,3-d]pyrimidine-6-carboxylate 
• 1380808-82-1 4-[(3-chloro-4-fluorophenyl)amino]-5-methylselenopheno[2,3-d]pyrimidine-6-carboxamide 
• 1380808-94-5 {4-[(3-chloro-4-fluorophenyl)amino]-5-methylselenopheno[2,3-d]pyrimidin-'6-yl}-N-(2-chloroethyl)carboxamide 
• 1578155-42-6 N-(3-chloro-4-fluorophenyl)-5-methyl-6-(3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidin-4-amine 
• 1578155-44-8 N-(3-chloro-4-fluorophenyl)-5-methyl-6-(3-p-tolyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidin-4-amine 
• 1578155-47-1 N-(3-chloro-4-fluorophenyl)-6-(3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)-5-methylselenopheno[2,3-d]pyrimidin-4-amine 
• 1578155-49-3 4-(6-(4-(3-chloro-4-fluorophenylamino)-5-methylselenopheno[2,3-d]pyrimidin-6-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)phenol 
• 1578155-51-7 N-(3-chloro-4-fluorophenyl)-5-methyl-6-(3-(4-nitrophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d]pyrimidin-4-amine 

Relevant academic research and scientific papers

Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1,2,4-triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3- d]pyrimidines

A series of 1,2,4-(triazolo[3,4-b][1,3,4]thiadiazol-6-yl)selenopheno[2,3-d] pyrimidines (10a-j) were synthesized with various substituted anilines and benzoic acids. Structures of newly synthesized compounds were established by IR, 1H & 13C NMR and LC-MS spectral data. The antioxidant activity of the synthesized compounds was evaluated by DPPH, NO and H 2O2 radical scavenging methods. The newly synthesized compounds were evaluated for their antimicrobial activity against Gram +ve and Gram -ve bacteria and antifungal activity by well diffusion method. Compounds 10d, 10h and 10i showed promising antioxidant, antibacterial as well as antifungal activity and these were found to be the most potent activity molecules when compared with that of standard drugs. Molecules docking studies have been performed on Staphylococcus aureus (SA) of Gram +ve bacteria.

SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF

The invention discloses 4-(arylamino)selenophenopyrimidine derivatives of formula (I), hydrates, solvates, isomers, or pharmaceutically acceptable salts thereof; process for their preparation and methods of treating or inhibiting or controlling a cell proliferative disorders, particularly cancer using said compounds. The invention further discloses pharmaceutical compositions comprising 4-(arylamino)selenophenopyrirnidine derivatives of formula (I) useful for the treatment or inhibition or control of cancer.