1380875-94-4Relevant academic research and scientific papers
Cyclization of 1,6-enynes catalyzed by gold nanoparticles supported on TiO2: Significant changes in selectivity and mechanism, as compared to homogeneous Au-catalysis
Gryparis, Charis,Efe, Christina,Raptis, Christos,Lykakis, Ioannis N.,Stratakis, Manolis
supporting information; experimental part, p. 2956 - 2959 (2012/08/07)
Gold nanoparticles supported on TiO2 (1.2 mol %) catalyze, for the first time under heterogeneous conditions, the cycloisomerization of a series of 1,6-enynes in high yields. In several cases, the product selectivity differs significantly as compared to homogeneous Au(I)-catalysis. Based on product analysis and stereoisotopic studies it is proposed that the major or exclusive pathway involves a 5-exo cyclization mode to form stereoselectively gold cyclopropyl carbenes that undergo a single cleavage pathway, in contrast to homogeneous Au-catalysis where the double cleavage pathway operates substantially.
