138091-53-9

Upstream product

• 138091-52-8 8-(tert-Butoxycarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 1021-25-6 1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1352950-95-8 tert-butyl 3-(4-aminobenzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate 
• 1352950-94-7 tert-butyl 3-(4-(methylsulfonamido)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate 
• 1352950-92-5 N-(4-((4-oxo-8-(4-oxo-4-phenylbutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)phenyl)methanesulfonamide 
• 138091-80-2 8-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-3-(4-nitro-benzyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 138091-54-0 3-(4-Nitro-benzyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 

Relevant academic research and scientific papers

D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE

Provided are D2 or D3 antagonist compounds and pharmaceutical compositions of formula I and pharmaceutically acceptable salts thereof, or isomers thereof, wherein R1, R2 and R3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D2 or D3 receptor from the compounds of the invention.

Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors

Two series of N-substituted spiperone analogues were prepared and evaluated in vitro to measure their affinities for dopamine D2 and serotonin 5-HT2 receptors. Substitution of the amide nitrogen with an alkyl group of five carbon uni