138098-76-7Relevant articles and documents
Rh-Catalyzed Asymmetric Hydrogenation of β-Substituted-β-thio-α,β-unsaturated Esters: Expeditious Access to Chiral Organic Sulfides
Liu, Gang,Han, Zhengyu,Dong, Xiu-Qin,Zhang, Xumu
, p. 5636 - 5639 (2018/09/12)
Rh/bifunctional bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydorgenation of both (Z)- and (E)-isomers of β-substituted-β-thio-α,β-unsaturated esters was successfully developed. This new asymmetric catalytic methodology provided highly efficient access to two enantiomers of chiral organic sulfides ethyl β-substituted-β-thio-propanoates with excellent results (up to 99% yield and >99% ee for (Z)-substrates, up to 99% yield and 98% ee for (E)-substrates, TON up to 5000), which are important intermediates in organic synthesis.
Catalytic asymmetric conjugate addition of thiols to α,β- unsaturated thioamides: Expeditious access to enantioenriched 1,5-benzothiazepines
Ogawa, Takanori,Kumagai, Naoya,Shibasaki, Masakatsu
supporting information; scheme or table, p. 8551 - 8554 (2012/09/21)
Softly does it: The title reaction proceeded under proton transfer conditions with a catalyst prepared from commercially available reagents to afford the desired product in high enantioselectivity. The reaction was compatible with a free amino group, thus allowing for expeditious access to enantiomerically enriched 1,5-benzothiazepines, which are important chemical entities in medicinal chemistry.
Catalytic asymmetric 1,6-michael addition of arylthiols to 3-methyl-4-nitro-5-alkenyl-isoxazoles with bifunctional catalysts
Pei, Qing-Lan,Sun, Hong-Wei,Wu, Zhi-Jun,Du, Xi-Lin,Zhang, Xiao-Mei,Yuan, Wei-Cheng
experimental part, p. 7849 - 7859 (2011/11/30)
(Figure presented) An enantioselective 1,6-Michael addition reaction of arylthiols to a wide range of 3-methyl-4-nitro-5-alkenyl-isoxazoles catalyzed by readily available Takemoto's thiourea catalyst has been developed. This reaction provides a useful cat
Inositols as chiral templates: 1,4-conjugate addition to tethered cinnamic esters.
Cousins, Ghislaine,Falshaw, Andrew,Hoberg, John O
, p. 2272 - 2274 (2007/10/03)
The 1,4-addition of thio nucleophiles to chiro-inositols containing a cinnamyl Michael acceptor proceeded with excellent diastereochemical induction and good yields. Cleavage of the inositol auxiliary provides beta-thio hydrocinnamic acids in >99% ee's.
A novel chemoenzymatic enantioselective synthesis of some clinically effective CNS drugs and related compounds
Kumar, Ashok,Ner, D H,Dike, Suneel
, p. 803 - 809 (2007/10/02)
We have demonstrated in this study a novel route for the synthesis of benzothiopyran and benzothiazepin ring systems along with the synthesis of optically pure, clinically effective drugs tomoxetine, fluoxetine and thiazesim.
