138109-49-6

Basic information

• Product Name: 2,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE
• Synonyms: 2,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE;2,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE, 0.5M SOLUTION IN TETRAHYDROFURAN;2,4-dimethoxyphenylmagnesium bromide solution;2,4-Dimethoxyphenylmagnesium bromide solution 0.5 in THF;2,4-DiMethoxyphenylMagnesiuM broMide, 0.5M in 2-MeTHF;2,4-Dimethoxyphenylmagnesium bromide 0.5M solution in THF;2,4-Dimethoxyphenylmagnesium bromide solution 0.5M in THF
• CAS NO: 138109-49-6
• Molecular Formula: C₈H₉BrMgO₂
• Molecular Weight: 241.36
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Chemical Synthesis;Grignard Reagents;Organometallic Reagents;Grignard Reagent
• Mol File: 138109-49-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: 1 °F
• Appearance: /
• Density: 0.960 g/mL at 25 °C
• Vapor Pressure: 0.195mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE(138109-49-6)
• EPA Substance Registry System: 2,4-DIMETHOXYPHENYLMAGNESIUM BROMIDE(138109-49-6)

Safety Data

• Hazard Codes: F,C,Xn
• Statements: 11-14-19-34-40-36/37
• Safety Statements: 16-29-33-45-36/37-26
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• Hazardous Substances Data: 138109-49-6(Hazardous Substances Data)

Usage

General Description

2,4-Dimethoxyphenylmagnesium bromide, also known as 2,4-Dimethoxyphenylmagnesiumbromide, is an organometallic compound used as a reagent in organic synthesis. It is derived from the Grignard reagent, and is commonly used to introduce the 2,4-dimethoxyphenyl group into organic compounds. 2,4-Dimethoxyphenylmagnesium bromide is highly reactive and is typically stored and handled under an inert atmosphere. 2,4-Dimethoxyphenylmagnesium bromide is widely used in pharmaceutical and chemical industries for the synthesis of various organic compounds. It is an important intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals.

InChI:InChI=1/C8H9O2.BrH.Mg/c1-9-7-4-3-5-8(6-7)10-2;;/h3-4,6H,1-2H3;1H;/q-1;;+2/p-1

Upstream product

• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 

Downstream Products

• 185416-31-3 [2-(2,4-Dimethoxyphenyl)-6-methoxybenzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]methanone 
• 152911-38-1 (2-amino-5-chlorophenyl)-(2,4-dimethoxyphenyl)methanone 
• 322640-10-8 (2S,5R)-2-[1-(2,4-Dimethoxy-phenyl)-1-methyl-ethyl]-5-methyl-cyclohexanone 
• 172467-17-3 (+/-)-N-(2'-fluorophenyl)-2-(α-hydroxy-2',4'-dimethoxybenzyl)pyrrole 
• 69470-81-1 (E)-1-phenyl-3-(2,4-dimethoxyphenyl)-1-propene 
• 149835-49-4 11β-(2,4-dimethoxyphenyl)-3,3-<2,2-dimethyl-1,3-propanediylbis(oxy)>-5α-estr-9-ene-5,17β-diol 
• 3698-23-5 Osmorhizole 
• 1139-83-9 urolithin B 
• 1187993-15-2 N-[(1Z)-(2,4-dimethoxyphenyl)(6-methylpyridin-2-yl)methylene]-2-methylpropane-2-sulfinamide 
• 1187993-17-4 N-[(2,4-dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-2-methylpropane-2-sulfinamide 
• 1187993-16-3 N-[(2,4-dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-2-methylpropane-2-sulfinamide 
• 1187992-07-9 N-[(2,4-Dimethoxyphenyl)(6-methylpyridin-2-yl)methyl]-4-hydroxy-2-pyridazin-3-ylpyrimidine-5-carboxamide 
• 1187993-14-1 1-(2,4-dimethoxyphenyl)-1-(6-methylpyridin-2-yl)methanamine hydrochloride 

Relevant articles and documents

Aggregation-Induced Singlet Oxygen Generation: Functional Fluorophore and Anthrylphenylene Dyad Self-Assemblies

The assembly of monomeric building blocks can manifest the display of new properties, including optical, mechanical, and electrochemical functionalities. In this study, we sought to develop a functional fluorophore self-assembly that can generate reactive oxygen species only when aggregated. With an anthrylphenylene (AP) group, negatively charged and neutral fluorescein units form non-fluorescent H-aggregates in aqueous solution because of the weak intermolecular interaction between the anthracene and fluorescein moieties. In stark contrast, a boron dipyrromethene (BODIPY) and AP dyad produces two-color-emissive aggregates through the formation of an intermolecular charge-transfer (CT) complex between the electron-rich anthracene and electron-deficient BODIPY moieties. Furthermore, to our surprise, the BODIPY and AP dyad aggregates generate singlet oxygen (1O2) and photocytotoxicity upon excitation, indicating that the BODIPY–anthracene CT state favors an intersystem crossing process. Based on X-ray crystallographic analysis, the lattice-like molecular packing between the BODIPY and AP moieties was determined to bring about the unprecedented aggregation-induced 1O2 generation (AISG).

Phosphororganische Verbindungen 106. Die Synthese Optisch Aktiver Tertiaerer Phosphine und Phosphinoxide mit Ortho-Substituierten Arylliganden

Compounds of the type C6H5Y (Y=OR, -NMe2), are lithiated with n-butyllithium (n-BuLi) in the ortho-position according (1) and transformed by special reactions to compounds of the type I and II. The representatives 7-22 of the type I with Y=OR ar