138118-26-0Relevant academic research and scientific papers
Reaction of gem-dibromocyclopropanes or iodobenzofuran with trialkylmanganate
Kakiya, Hirotada,Inoue, Rie,Shinokubo, Hiroshi,Oshima, Koichiro
, p. 2131 - 2137 (2007/10/03)
Treatment of gem-dibromocyclopropanes with trialkylmanganate, derived from manganese(II) chloride and three equivalents of Grignard reagent or alkyllithium, followed by an addition of electrophiles provided dialkylated cyclopropanes in good yields. It was
Ortho-substituted aromatic ether compounds and their use in pharmaceutical compositions for pain relief
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, (2008/06/13)
The invention provides compounds of formula I: STR1 wherein A, B, D, X, R1, and R3 have any of the values defined in the specification, as well as N-oxides thereof, S-oxides thereof, pharmaceutically acceptable salts thereof, and in vivo hydrolizable esters and amides thereof, that are useful to relieve pain. The invention also provides pharmaceutical compositions as well as synthetic and therapeutic methods relating to such compounds.
CARBON-CARBON BOND FORMATION BY THE REACTION OF ORGANOLITHIUMS WITH α-LITHIATED CYCLIC ENOL ETHERS. STEREOSELECTIVE SYNTHESIS OF β- AND γ-HYDROXY DI- AND TRISUBSTITUTED ALKENES
Nguyen, Thinh,Negishi, Ei-ichi
, p. 5903 - 5906 (2007/10/02)
α-Lithiation of dihydrofuran, benzofuran, and dihydropyran followed by treatment with various organolithiums stereoselectively produces in good yields the corresponding ring-opened (E)-alkenyllithiums, i. e., (E)-β(or γ)-hydroxy-ω-alkenyl-ω-lithioalkenes, the lithium atom of which can be readily replaced with H, D, or C groups, such as CO2 or Me.
