138128-76-4

Basic information

• Product Name: 1,2,4-Thiadiazole-5-methanol, 3-phenyl-
• CAS NO: 138128-76-4
• Molecular Formula: C9H8N2OS
• Molecular Weight: 192.241
• Mol File: 138128-76-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,2,4-Thiadiazole-5-methanol, 3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Thiadiazole-5-methanol, 3-phenyl-(138128-76-4)
• EPA Substance Registry System: 1,2,4-Thiadiazole-5-methanol, 3-phenyl-(138128-76-4)

Safety Data

• Hazardous Substances Data: 138128-76-4(Hazardous Substances Data)

Upstream product

• 50483-79-9 ethyl 3-phenyl-1,2,4-thiadiazole-5-carboxylate 

Downstream Products

• 505081-79-8 5-formyl-3-phenyl-1,2,4-thiadiazole 
• 138129-05-2 [4-Oxo-3-(3-phenyl-[1,2,4]thiadiazol-5-ylmethyl)-3,4-dihydro-phthalazin-1-yl]-acetic acid ethyl ester 
• 138129-12-1 [4-Oxo-3-(3-phenyl-[1,2,4]thiadiazol-5-ylmethyl)-3,4-dihydro-phthalazin-1-yl]-acetic acid 
• 138128-82-2 5-(bromomethyl)-3-phenyl-1,2,4-thiadiazole 

Relevant articles and documents

Heteroarylnitrones as drugs for neurodegenerative diseases: Synthesis, neuroprotective properties, and free radical scavenger properties

New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative damage and the death induced by exposure to hydrogen peroxide. These heteroarylnitrones showed excellent peroxyl free radical absorbance capacities, analyzed by oxygen radical absorbance capacity (ORAC) assay with fluorescein as the fluorescent probe, ranging from 1.5- to 16.5-fold the value of the reference nitrone, α-phenyl-N-tert-butylnitrone (PBN). The electron spin resonance spectroscopy (ESR) demonstrated the ability of these derivatives to directly trap and stabilize oxygen, carbon, and sulfur-centered free radicals. These results demonstrated the potential use of these heteroarylnitrones as neuroprotective agents in preventing the death of cells exposed to enhanced oxidative stress and damage.