Ribocil is a synthetic mimic of riboflavin 5'-monophosphate (FMN) that functions as an inhibitor of FMN riboswitch-mediated expression of ribB, a gene responsible for the synthesis and transport of riboflavin. It effectively depletes cellular levels of riboflavin and inhibits the growth of E. coli.
1381289-58-2
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Basic information
- Product Name: Ribocil
- Synonyms: Ribocil
- CAS NO:1381289-58-2
- Molecular Formula: C19H22N6OS
- Molecular Weight: 382.48258
- EINECS: -0
- Product Categories: N/A
- Mol File: 1381289-58-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 587.8±60.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.41±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 8.44±0.50(Predicted)
- CAS DataBase Reference: Ribocil(CAS DataBase Reference)
- NIST Chemistry Reference: Ribocil(1381289-58-2)
- EPA Substance Registry System: Ribocil(1381289-58-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1381289-58-2(Hazardous Substances Data)
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1381289-58-2 Usage
Uses
Used in Pharmaceutical Industry:Ribocil is used as an inhibitor for targeting the ribB gene, which is responsible for the synthesis and transport of riboflavin. Its application in this industry is due to its ability to deplete cellular levels of riboflavin with an IC50 value of 0.3 μM and inhibit E. coli growth with an MIC value of 2 μg/ml.
Used in Research and Development:
Ribocil serves as a valuable tool in research and development for studying the role of riboflavin synthesis and transport in bacterial growth and metabolism. Its ability to inhibit the ribB gene makes it a useful compound for understanding the underlying mechanisms and potential therapeutic targets for various diseases and conditions.
Used in Antimicrobial Applications:
Ribocil is used as an antimicrobial agent, specifically against E. coli, by inhibiting the growth of the bacteria through the depletion of cellular riboflavin levels. This application is significant for the development of new strategies to combat bacterial infections and resistance.
Used in Biochemical Studies:
Ribocil is utilized as a research compound in biochemical studies to investigate the role of FMN riboswitches in gene regulation and the biosynthesis of riboflavin. Its ability to compete with the natural ligand and inhibit the ribB gene provides insights into the molecular mechanisms of gene expression and regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 1381289-58-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,1,2,8 and 9 respectively; the second part has 2 digits, 5 and 8 respectively.Calculate Digit Verification of CAS Registry Number 1381289-58:
(9*1)+(8*3)+(7*8)+(6*1)+(5*2)+(4*8)+(3*9)+(2*5)+(1*8)=182
182 % 10 = 2
So 1381289-58-2 is a valid CAS Registry Number.
1381289-58-2Upstream product
1381289-58-2Downstream Products
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Ribocil
