Tyroserleutide is a synthetic peptide composed of tyrosine, serine, and leucine, derived from the amino acid sequence of human prothrombin, a protein that plays a crucial role in the blood clotting cascade. This peptide has garnered attention for its potential applications in cancer treatment, particularly hepatocellular carcinoma, due to its ability to induce apoptosis and inhibit cell proliferation. Furthermore, tyroserleutide exhibits immunomodulatory effects, such as enhancing the activity of natural killer cells and regulating cytokine expression, positioning it as a promising candidate for therapeutic intervention in cancer.
138168-48-6
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Basic information
- Product Name: Tyroserleutide
- Synonyms: Tyroserleutide;alpha-BCP[7-9];CMS-024;YSL;Tyroserleutide Hydrochloride
- CAS NO:138168-48-6
- Molecular Formula: C18H27N3O6
- Molecular Weight: 381.42
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: 153-155 °C
- Boiling Point: 763.8±60.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.293±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 3.28±0.10(Predicted)
- CAS DataBase Reference: Tyroserleutide(CAS DataBase Reference)
- NIST Chemistry Reference: Tyroserleutide(138168-48-6)
- EPA Substance Registry System: Tyroserleutide(138168-48-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 138168-48-6(Hazardous Substances Data)
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138168-48-6 Usage
Uses
Used in Cancer Treatment:Tyroserleutide is used as an anti-tumor agent for hepatocellular carcinoma, where it demonstrates its efficacy by inducing apoptosis and inhibiting the proliferation of cancer cells. This targeted approach to cancer treatment could potentially offer a more effective and less invasive alternative to traditional chemotherapy.
Used in Immunomodulation:
In the field of immunotherapy, tyroserleutide is utilized as an immunomodulatory agent to enhance the body's natural defense mechanisms against cancer. It increases the activity of natural killer cells, which are crucial in identifying and eliminating cancer cells, and modulates cytokine expression, which can influence the immune response and overall tumor microenvironment.
As research continues, the potential applications of tyroserleutide may expand to include other types of cancer and possibly other therapeutic areas, given its multifaceted effects on both tumor cells and the immune system.
Check Digit Verification of cas no
The CAS Registry Mumber 138168-48-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,1,6 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.Calculate Digit Verification of CAS Registry Number 138168-48:
(8*1)+(7*3)+(6*8)+(5*1)+(4*6)+(3*8)+(2*4)+(1*8)=146
146 % 10 = 6
So 138168-48-6 is a valid CAS Registry Number.
138168-48-6Upstream product
138168-48-6Downstream Products
138168-48-6Related news
The effect of tripeptide Tyroserleutide (cas 138168-48-6) (YSL) on animal models of hepatocarcinoma08/17/2019
This study aimed to observe the effects of tyroserleutide (tyrosyl-seryl-leucine, YSL) on the survival time of mice transplanted with the ascitic fluid-type hepatocarcinoma H22, as well as the inhibitory effect of tyroserleutide on the human hepatocarcinoma Bel-7402 that was transplanted into nu...detailed
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Tyroserleutide
