138175-49-2

Basic information

• Product Name: AKOS BBS-00008114
• Synonyms: AURORA 9368;CHEMBRDG-BB 5221473;AKOS BBS-00008114;(2E)-2-CYANO-3-(4-HYDROXY-3-METHOXYPHENYL)ACRYLAMIDE;AKOS A1230-0339
• CAS NO: 138175-49-2
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.21
• Mol File: 138175-49-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 488.8°C at 760 mmHg
• Flash Point: 249.4°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 3.52E-10mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: AKOS BBS-00008114(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS BBS-00008114(138175-49-2)
• EPA Substance Registry System: AKOS BBS-00008114(138175-49-2)

Safety Data

• Hazardous Substances Data: 138175-49-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10N2O3/c1-16-10-5-7(2-3-9(10)14)4-8(6-12)11(13)15/h2-5,14H,1H3,(H2,13,15)/b8-4+

Upstream product

• 121-33-5 vanillin 
• 3696-12-6 2-(4-hydroxy-3-methoxybenzylidene)malononitrile 
• 107-91-5 cyanoacetic acid amide 

Relevant articles and documents

LQFM184: A Novel Wide Ultraviolet Radiation Range Absorber Compound

The use of sunscreen has become an indispensable daily routine since UV radiation is a critical environmental stress factors for human skin. This study focused on the design, synthesis, thermal/chemical stability and efficacy/safety evaluations of a new h

Use of a water solution of surfactant in Knoevenagel reaction

In reaction of vanillin with active methylene compounds in the presence of detergent Oksipav AP the corresponding substituted alkenes were formed in high yields.

Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

The 3-aryl-2-cyanoacrylamide scaffold was designed as core pharmacophore for inhibitors of the Dengue and West Nile virus serine proteases (NS2B-NS3). A total of 86 analogs was prepared to study the structure-activity relationships in detail. Thereby, it turned out that the electron density of the aryl moiety and the central double bond have a crucial influence on the activity of the compounds, whereas the influence of substituents of the amide residue is less relevant. The para-hydroxy substituted analog was found to be the most potent inhibitor in this series with a Ki-value of 35.7 μM at the Dengue and 44.6 μM at the West Nile virus protease. The aprotinin competition assay demonstrates a direct interaction of the inhibitor molecule with active centre of the Dengue virus protease. The target selectivity was studied in a counterscreen with thrombin and found to be 2.8:1 in favor of DEN protease and 2.3:1 in favor of WNV protease, respectively.