1381802-02-3

Basic information

• Product Name: 4-amino-1,3-diphenyl-5-p-tolyl-1H-pyrrol-2(5H)-one
• Synonyms: 4-amino-1,3-diphenyl-5-p-tolyl-1H-pyrrol-2(5H)-one
• CAS NO: 1381802-02-3
• Molecular Weight: 340.425
• Mol File: 1381802-02-3.mol

Chemical Properties

• CAS DataBase Reference: 4-amino-1,3-diphenyl-5-p-tolyl-1H-pyrrol-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1,3-diphenyl-5-p-tolyl-1H-pyrrol-2(5H)-one(1381802-02-3)
• EPA Substance Registry System: 4-amino-1,3-diphenyl-5-p-tolyl-1H-pyrrol-2(5H)-one(1381802-02-3)

Safety Data

• Hazardous Substances Data: 1381802-02-3(Hazardous Substances Data)

Upstream product

• 64101-91-3 2-(4-methylphenyl)-2-(phenylamino)acetonitrile 
• 1381803-44-6 C₂₃H₂₀N₂O 

Relevant articles and documents

Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones

Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.