1381807-98-2Relevant academic research and scientific papers
Rhodium(I)-catalyzed Pauson-Khand-type [3 + 2 + 1] cycloaddition reaction of ene-vinylidenecyclopropanes and CO: A highly regio- and stereoselective synthetic approach for the preparation of aza- and oxa-bicyclic compounds
Lu, Bei-Li,Wei, Yin,Shi, Min
experimental part, p. 4601 - 4609 (2012/07/30)
In this paper, a novel Rh(I)-catalyzed Pauson-Khand-type [3 + 2 + 1] cycloaddition reaction of ene-vinylidenecyclopropanes (Ene-VDCPs) and carbon monoxide (CO) has been developed to furnish a series of aza- and oxa-bicyclic compounds in moderate to good yields in a highly regio- and diastereoselective manner, which provides an alternative and efficient synthetic approach for the access of bicyclic cyclohexanone frameworks. The substrate scope and limitations and a plausible mechanism are discussed.
