1381841-09-3

Basic information

• Product Name: C₂₇H₃₅N₇O₄S₂
• CAS NO: 1381841-09-3
• Molecular Weight: 585.751
• Mol File: 1381841-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₅N₇O₄S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₅N₇O₄S₂(1381841-09-3)
• EPA Substance Registry System: C₂₇H₃₅N₇O₄S₂(1381841-09-3)

Safety Data

• Hazardous Substances Data: 1381841-09-3(Hazardous Substances Data)

Upstream product

• 16234-14-3 2,4-dichlorothieno[3,2-d]pyrimidine 
• 885618-31-5 2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde 
• 885675-66-1 4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine 
• 885698-97-5 2-chloro-4-morpholinylthiophene[3,2-d]pyrimidine-6-methanol 
• 1381841-06-0 4-(2-chloro-6-(chloromethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 
• 1381841-07-1 4-(2-hydrazinyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 
• 162971-77-9 2-(β-methylallyl)phenol-6-carbaldehyde 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 38002-87-8 O-methallylsalicylaldehyde 
• 90-02-8 salicylaldehyde 
• 16233-51-5 1H-thieno[3,2-d]pyrimidine-2,4-dione 
• 16234-15-4 2-chloro-4-morpholinothieno[3,2-d]pyrimidine 

Relevant articles and documents

Synthesis and cytotoxic activity of novel 2,6-disubstituted-4-mor- pholinothieno[3,2-d]pyrimidines as potent anti-tumor agents

A series of 2,6-disubstituted-4-morpholinothieno[3,2-d]pyrimidine derivatives were synthesized and their cytotoxic activity against H460, HT-29, MDA-MB-231, U87MG and H1975 cancer cell lines were evaluated in vitro. Most of the target compounds exhibited moderate to excellent activity to the tested cell lines. The most promising compound 23 (0.84 μmol/L, 0.23 μmol/L, 2.52 μmol/L, 1.80 μmol/L) was 1.0, 2.9, 29.3 and 4.3 times more active than GDC-0941 (0.87 μmol/L, 0.66 μmol/L, 73.8 μmol/L, 7.77 μmol/L) against H460, HT-29, MDA-MB-231 and U87MG cell lines, respectively.