1381876-79-4

Upstream product

• 880-87-5 5,7-dimethoxyindan-1-one 
• 71088-95-4 ethyl 5,7-dimethoxyindan-1-one-2-glyoxalate 
• 16909-11-8 3-(3,5-dimethoxyphenyl)acrylic acid 
• 717-94-2 3-(3,5-dimethoxyphenyl)propionic acid 
• 82218-06-2 6,8-dimethoxy-1H-2-benzopyran-1,3(4H)-dione 
• 106-49-0 p-toluidine 
• 4778-99-8 2-carboxymethyl-4,6-dimethoxy-benzoic acid 

Relevant academic research and scientific papers

Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H, 4H)-diones in vitro and in vivo

Six 2-(2-acylaminobenzothiazol-6-yl)isoquinoline-1,3(2H,4H)-diones (1a-1f) and five 2-arylisoquinoline-1,3(2H,4H)-diones (1g-1k) were synthesized by refluxing homophthalic anhydrides with 2-acylaminobenzothiazolyl-6-amine or substituted aniline in glacial acetic acid. The cytotoxic activities of 1a-1k were evaluated via MTT method against A431, A549, and PC3. Compound 1b relatively displayed a higher cytotoxic activity than the others. The antitumor effect of 1b were evaluated in established nude mice PANC-1 xenograft model. The results suggest that compound 1b could potentially inhibit tumor growth.